|
KMID : 1134820070360111371
|
|
Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 11 p.1371 ~ p.1376
|
|
|
Antimutagenic and Cytotoxic Effects of Hovenia dulcis Thumb Leaves Extracts
|
|
Park Sun-Hee
Chang Eun-Young
|
|
|
Abstract
|
|
|
|
The effect of Hovenia dulcis Thumb leaves on the mutagenicity in salmonella assay and inhibitory effects on the growth of cancer cells were studied. On antimutagenicity as evaluated by Ames test, the extract and fractions of Hovenia dulcis Thumb leaves had no effect on the mutagenicity by themselves. However, methanol extract and fractions from Hovenia dulcis Thumb showed strong inhibitory effect on the mutagenesis induced by N-methyl-N’-nitro-N-nitroso-guanidine (MNNG) and benzo(a)pyrene (B(a)P). Among the solvent fractions of methanol extract, the hexane, chloroform and butanol fraction exhibited stronger inhibitory activity against MNNG and B(a)P induced mutagenesis than water fraction. For anticancer effects, Hovenia dulcis Thumb leaves extract and fractions against cancer cell lines including HepG2 and HT29 were investigated. The methanol extract, the hexane fraction and the chloroform fraction of Hovenia dulcis Thumb leaves inhibited growth of cancer cells but they had no effect on the cytotoxicity of normal human liver cells under the same conditions.
|
|
|
KEYWORD
|
|
|
antimutagenic effect, Hovenia dulcis Thumb, cytotoxic effect
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|